Keto Chicken Florentine Bake with Artichoke Hearts (Low-Carb Casserole, No Cream Cheese)

This Keto Chicken Florentine Bake is the casserole I make when I want something creamy without reaching for cream cheese again. Chicken, spinach, and artichoke hearts bake together under a buttery, crunchy topping, and the whole thing comes together as one dish.

This post may contain affiliate link(s). As an Amazon Associate, I earn from qualifying purchases. See Disclosure.

• 
• 
• 
• 
• 
• 

I lean on this one for using up leftover chicken, whether it’s baked, grilled, or pulled from a rotisserie bird. It’s a genuinely complete meal on its own, protein, vegetables, and cheese all in one dish, which makes weeknight dinner decisions a lot simpler.

Watch the label on marinated artichoke hearts. Some brands sneak in added sugar or starch you wouldn’t expect in a jar of vegetables.

Chef Jenn’s Take on Keto Chicken Florentine Bake with Artichoke Hearts

Most creamy keto casseroles lean entirely on cream cheese to get that rich texture, and if you’re tired of cream cheese showing up in every single dish, that gets old fast. This one builds richness a different way, through eggs, heavy cream, and a generous amount of cheese instead.

Leaving the artichoke hearts in large chunks instead of chopping them small is what keeps their flavor and texture present in the finished dish. Chop them too fine and they basically disappear into the casserole, and you lose one of the best parts of the whole thing. For more keto casseroles like this one, check out my Casseroles collection.

What You’ll Love About Keto Chicken Florentine Bake with Artichoke Hearts

• It’s a genuinely complete meal in one dish, so there’s no scrambling to put together a side at the last minute.
• No cream cheese anywhere in this one, which is a welcome break if you’ve hit your limit on it showing up in every keto recipe.
• It’s a smart way to use up leftover chicken, so it’s an easy answer to “what do I do with all this rotisserie chicken” during a busy week.

Ingredients

• Onion – Finely chopped.
• Butter – Salted or unsalted, adjust added salt slightly if using unsalted.
• Garlic – Fresh, minced.
• Eggs
• Heavy whipping cream
• Italian seasoning – Check the label for a sugar-free blend.
• Crushed red pepper flakes
• Salt and pepper
• Cooked chicken – Cubed or chopped. Leftover baked, grilled, or rotisserie chicken all work well.
• Monterey Jack cheese – Shredded. Mozzarella, cheddar, or colby all work as substitutes.
• Artichoke hearts – Drained and cut into large chunks. Don’t chop them too small, or they get lost in the casserole.
• Frozen chopped spinach – Thawed and squeezed dry. Fresh spinach works too, cook it down first before adding.
• Parmesan cheese
• Pork panko – Or almond flour, for the topping.

How To Make The Best Keto Chicken Florentine Bake With Artichoke Hearts

Scroll down for the full recipe card with exact measurements and printable instructions.

Preheat the oven to 350°F and lightly spray a baking dish with nonstick cooking spray.

Cook the onion in butter over medium heat until translucent, about 5 minutes. Add the minced garlic and cook for another minute, until fragrant.

Whisk the eggs, heavy whipping cream, Italian seasoning, salt, pepper, and red pepper flakes together in a large bowl.

Add the chicken, cheese, artichoke hearts, spinach, cooked onion, and garlic to the egg mixture. Mix well to combine everything evenly.

Melt the remaining butter and stir it together with the Parmesan cheese and pork panko to make the topping.

Transfer the chicken mixture into the prepared baking dish, then sprinkle the Parmesan and panko topping evenly over the top.

Bake for 15 to 20 minutes, until bubbly in the center and golden on top.

Make It A Meal

I round this out with a simple green salad and Green Goddess Dressing on the side, though this casserole is a complete meal on its own. For a veggie-forward addition, Asparagus Salad with Lemon and Parmesan makes a bright, chilled contrast to the warm, cheesy bake. If you want another salad option in the mix, Classic Caprese Salad works well too.

Storage

Store leftovers in an airtight container in the fridge for 3 to 4 days. Reheat individual portions in the microwave, or in the oven at 350°F until warmed through, which helps the topping crisp back up.

Frequently asked questions

WANT EVEN MORE EASY KETO DIET RECIPES?

I’m always in the kitchen creating new recipes, and while some of them are big hits, I get some misses, too. But these are some of my favorite all-time recipes:

• Crack cauliflower
• This dump-and-go Instant Pot recipe
• Tex-Mex beefy goodness
• Grilled vegetables
• Keto French dip chaffwich